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Most importantly, except for pioglitazone (having a limited use due to side effects) and GLP1 analogs, no drug has proved effective in preventing / delaying the progressive failure of beta cells in T2D patients
However, they are not a magic stand-alone weight loss tool
[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations
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Injectable folic acid preparations containing benzyl alcohol should be avoided in neonates because benzyl alcohol has been associated with gasping syndrome, a potentially fatal condition characterized by metabolic acidosis and CNS, respiratory, circulatory, and renal dysfunction
