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Subjects taking the treatment supplement were significantly more resistant to oxidative damage than those taking the placebo

Lancet 372, 12401250

-butyrobetaine hydroxylase (BBOX1), a cytosolic dimeric protein, catalyzes the last step converting -butyrobetaine (-BB) to L-carnitine 3,4 (Fig

Understanding why helps set appropriate expectations

This can result in a reduced need for thyroid hormone replacement, particularly in patients who initially required higher doses due to obesity-related factors like increased inflammation or altered hormone metabolism