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Following exposure to EChLESs, ferroptosis was induced in HCC cells characterized by the crumpled and broken mitochondria, elevated mitochondrial reactive oxygen species (mtROS) levels, inactivated GSH-dependent antioxidant defense system, increased intracellular iron levels and the excessive lipid peroxidation

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Without automatic substitution authority, the biosimilar company must deploy a commercial team equivalent in scale to a branded drug launch to specifically drive prescribers toward its product a cost structure that fundamentally undermines the low-price, high-volume generic business model

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