Krajnc, Nik (Department of Neurology, Medical University of Vienna)
Indeed, GLP-1 RA users in our cohort exhibited more frequent risk factors for pancreatic cancerincluding older age, obesity, type 2 diabetes, and prior gastrointestinal disorderssuggesting a background of increased vulnerability
Phase 2 data showed the 8mg combined group achieved 22.8% mean weight reduction at 48 weeks, which is only 1.4 percentage points less than the 12mg group
What makes Mounjaro different from semaglutide-based products is that it activates two hormone receptors at once: the GLP-1 receptor (which Ozempic and Wegovy target) and the GIP receptor (which plays a role in how the body processes fat and regulates insulin response)
Fraternale et al., 2017), as well as conferring protection against oxidative stress caused by microbial, parasitic and viral infections such as SARS-CoV-2 that causes COVID-19 disease (Morris et al., 2013