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Effector T cells that secrete GM-CSF [8], Th17 cells that produce glutamate [9], CXCR4 + T cells with GM-CSF [10], regulatory T cells (Tregs) [11], CD8 + T lymphocytes [12], and regulatory B cells (B regs) that secrete IL-10 and IL-35 are only a few newly identified immune cells in MS [13, 14]

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5-Amino-1MQ inhibits NNMT activity, preserving nicotinamide for NAD+ synthesis and preserving SAM for epigenetic methylation producing a metabolic state in pre-clinical models that has been described as functionally resembling caloric restriction or elevated physical activity at the cellular level