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MNP-Associated Thrombotic and Hemorrhagic Complications Emerging evidence suggests that MNP exposure may interfere with hemostatic balance and contribute to coagulation abnormalities potentially associated with thrombotic and hemorrhagic complications [40, 64]

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In a study involving temporarily induced insulin resistance through treatment of non-esterified fatty acid (NEFA), metformin improved extrahepatic glucose utilization in patients with T2DM potentially by promoting microvascular perfusion [50, 51]