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All GLP-1 receptor agonists and tirzepatide carry a boxed warning for risk of thyroid C-cell tumors and are contraindicated in patients with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

A patient on 15 mg who stops cold has no pharmacological appetite suppression within 30 days (tirzepatide half-life is approximately 5 days

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Most deaths are caused by excess iron, leading to cardiac complications

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