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Most common side-effects The most common side effects are gastrointestinal and often improve over time: Nausea (most common) Vomiting Constipation or diarrhea GERD / acid reflux Bloating and early satiety Fatigue Less common but more serious risks include: Gallbladder disease Pancreatitis (rare) 10

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Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations