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It is widely known that mitochondrial dysfunction (high ROS production, apoptotic cells, decreased m, and low cellular ATP levels) boosts the pathogenesis of KOA because it involves lipid homeostasis and cytokine release and promotes cell apoptosis [14, 15]

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This is why the studies for CVD, chronic kidney disease (CKD), and obstructive sleep apnea (OSA) were so significant

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Reviewed February 2026