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There is no strong controlled-trial data showing that methionine, inositol, and choline injections produce clinically meaningful fat loss beyond what the accompanying diet, exercise, and supervision account for

doi: 10.1016/j.ygcen.2017.12.007 154 ZengXXieYJLiuYTLongSLMoZC

Phase 2 trials showed up to 24% body weight reduction at the highest dose, and Phase 3 data from the TRIUMPH program pushed that number even higher, reaching 28.7% in participants with obesity and knee osteoarthritis

Timing injections before physical therapy sessions (30 to 60 minutes prior) may optimize this synergy