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Most practitioners start tirzepatide at its lowest dose of 2.5 mg regardless of the previous semaglutide dose to minimize gastrointestinal side effects during the transition

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The gut mucosal response appears consistent across sex and hormonal status, making gut lining indications a strong match for female patients who are dealing with the GI consequences of hormonal fluctuation, antibiotic cycles, or inflammatory conditions

This hormonal selectivity makes it the GHRP with the most favorable tolerability profile