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Motor neurons overexpressing mSOD1 secreted a proportion of the mSOD1 protein [134], which might be recognized by the C1q-induced complement system and mark the motor neurons for attack by immune cells
The most common reactions include transient digestive upset (nausea, vomiting, stomach cramps, or diarrhea), a mild fishy body odor, headache, or soreness and redness where the injection is given
Pharmacokinetic (PK) objectives vary: some protocols test short-acting pulses that mirror meal-time signaling, while others emphasize sustained exposure to probe AUC-dependent effects
Furthermore, they contribute to weight loss and serve as an alternative to insulin, representing a non-insulin approach to diabetes management
doi:10.1007/978-3-319-22539-5_14
