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Renal OCTN2 expression and activity increase when the carnitine concentration is reduced in the plasma and/or glomerular filtrate, whereas OCTN2 mRNA expression levels remain unchanged in the gut, liver, or skeletal muscle [254], highlighting the central role of the kidney in maintaining carnitine homeostasis
This process is regulated by Bcl-2 family proteins
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It also modulates NF-kB, one of the primary inflammatory signaling pathways involved in chronic low-grade inflammation
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