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In further accordance, the tested agents (i) increase, rather than decrease, and water intake, (ii) block alcohol-induced hyperlocomotion and dopamine release in NAc which are parameters unaffected by aversion, and (iii) attenuates drug-related responses that are driven by reward rather than by malaise [for review see (115)]
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Intracellular proteolytic processing of precursor polypeptides is an essential step in the maturation of many proteins such as plasma proteins, hormones, neuropeptides, and growth factors 331
Premature discontinuation before reaching therapeutic doses or adequate treatment duration prevents full pharmacological effect
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