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One study found thigh bioavailability ran about 12% lower compared to the abdomen

Canagliflozin causes glycosuria (up to 70 grams/day)

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This HO-CO pathway has been recently proposed to be involved in the defence against oxidative stress and the deleterious effects of NO, since it removes the cytotoxic free heme, and produces some molecules with antioxidant and anti-inflammatory effects, such as biliverdin and CO [8, 3840]