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Figure 3 In conclusion, SLC7A11 has a pro-survival effect, and SLC7A11-mediated cystine uptake can help cells re-establish redox homeostasis in response to oxidative stress, whereas inhibition of SLC7A11 can lead to depletion of cellular GSH and thus make the cells more sensitive to chemotherapy or radiotherapy
Despite nearly identical body weights, food intake, and muscle masses, the proteomes differed meaningfully between the semaglutide group and the pair-fed group
Migraine, brain glucose metabolism and the Neuroenergetic hypothesis: a scoping review
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Similar effects have been demonstrated in osteoarthritis models, where liraglutide facilitates macrophage polarization toward the anti-inflammatory M2 phenotype by downregulating M1-associated markers such as Mcp-1 and Cd38, while upregulating M2-related genes including Erg-2, reducing the secretion of pro-inflammatory cytokines and mitigates inflammatory responses (Meurot et al., 2022)
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