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Metastasis is strongly reduced by the matrix metalloproteinase inhibitor galardin in the MMTV-PymT transgenic breast cancer model
Melanotan 2 is used in laboratory research to investigate melanocortin system activity, including pigmentation processes and related biological mechanisms
Diabetes Care 41(9):19811990
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These two substitutions , the Nle4 and D-Phe7 modifications and were introduced through the systematic structure-activity relationship programme in Victor Hrubys laboratory at the University of Arizona that established the pharmacophore requirements for melanocortin receptor agonism and produced MT-1 as a more potent, metabolically stable, and pharmacologically tractable research tool than native -MSH
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