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By stimulating insulin secretion and inhibiting glucagon release, Semaglutide helps maintain stable blood sugar levels, reducing the risk of complications associated with diabetes

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Perioperative implications were evaluated with emphasis on orthopaedic surgical risk domains relevant to total joint arthroplasty (TJA), including wound complications, hematoma formation, immune modulation, infection susceptibility, heterotopic ossification, and implant fixation considerations

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The metabolic change affects the balance of pro-inflammatory and anti-inflammatory cytokines and other immune factors, promoting the decline of the gut epithelial barrier