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Altered bacterial composition: changes in bacterial types and amounts observed after NNMT inhibition in models

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Patients on any oral antihyperglycemic agent in monotherapy (N=212) or on a PPAR agent in combination therapy (N=106) or not on an antihyperglycemic agent (off therapy for at least 8 weeks, N=34) were switched to monotherapy with pioglitazone (at a dose of 30-45 mg per day), and completed a run-in period of approximately 12 weeks in duration

This was accompanied by reduced intestinal fat absorption and increased non-coupled respiration in brown adipose tissue (BAT), which attenuated hepatic steatosis through weight loss