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The answer is: it depends

The dual benefit of weight loss and glucose control makes it the obvious choice

[1] [3] Importantly, patients should seek urgent medical attention if they experience severe or persistent abdominal pain (especially if radiating to the back), repeated vomiting, inability to keep fluids down, signs of dehydration, or jaundice, as these may indicate serious conditions such as pancreatitis or gallbladder disease

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The hyperinsulinemic euglycemic clamp technique is the gold standard for measuring insulin sensitivity