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Doctors may discuss whether a washout period, dose step-down, or cautious retitration would be needed based on your tolerance history

As with any peptide, sourcing matters enormously

doi: 10.1016/S0140-6736(18)32260-8 67 FriasJPNauckMAVanJBensonCBrayRCuiXet al

Tirzepatide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2