Manual model building and structure refinement were carried out with PHENIX (version 1.20.1-4487) 29 , Coot (version 0.9.6) 30 and phenix-refine, respectively
Each batch released after stringent internal quality checks
The liver is particularly susceptible to oxidative stress due to its central role in metabolizing various substances, including drugs and alcohol
There are two important classes of enzymes with which glutathione can be associated: Glutathione peroxidases , which catalyze the reduction reaction of hydrogen peroxide ( H2O2 ) to water, removing this toxic substance from the body Phospholipid-hydroperoxide glutathione peroxidases , which catalyze the reduction of an oxidized phospholipid by reactive oxygen species to its physiological form
References Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, Seiwerth S