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In an article published by Eureka Health, Sina Hartung, of Harvard Medical School, offered some tips that can amplify the medication's effect and allow people to lock into successful long-term maintenance

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Integrating behavioral support to enhance adherence

Other factors include: Underlying cause of deficiency : Pernicious anaemia, malabsorption disorders, or dietary insufficiency may affect treatment response Medication use : Metformin and proton pump inhibitors can reduce gastrointestinal B12 absorption (though this does not affect the efficacy of intramuscular injections) Individual variation : Differences in how efficiently your body utilises the injected vitamin Adherence to treatment schedule : Missing injections or delaying maintenance doses can slow recovery Discussing these factors with your healthcare provider helps set realistic expectations for your treatment journey

doi:10.2165/00003495-197816010-00002