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Old data generated with an approved drug may not describe todays compounded or research-grade material

Some remarkable results are the decline of PSA after combination of metformin with bicalutamide after 8 weeks (42.1% bicalutamide + metformin vs 11.1% only bicalutamide) in PC patients with overweight (ClinicalTrial.gov ID NCT02614859), and with castration after 7 months (placebo PSA 58.2 ng/mL vs metformin PSA 8.36 ng/mL, ClinicalTrial.gov ID NCT01620593, [191]), and its detection in the prostatic tissue after consumption for 12 weeks, but without changes in tumor progression markers (ClinicalTrials.gov ID NCT01433913, [192])

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FSP1 accomplishes this through its ubiquinone oxidoreductase activity, which produces panthenol by decreasing the incomplete oxidation product of ubiquinone (CoQ10), semihydroquinone [39]

Robust trials showing injected MIC causes independent fat loss are lacking