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CagriSema: 15.6% weight loss and 2.2 pp HbA1c reduction

Meat, poultry, fish, seafood, eggs, and dairy products contain sufficient B12 to avoid deficiency

The common link is that GLP-1s activate receptors that then work on driving down metabolic risk factors through the following mechanisms: Enhancing glucose dependent insulin secretion Slowing gastric emptying and decreasing appetite Reducing postprandial glucagon and food intake UpToDate 2 : (1) ingestion of food results in (2) release of gastrointestinal peptides (GLP-1 and GIP: glucose-dependent insulinotropic polypeptide, gastric inhibitory peptide) and (3) pancreatic beta cell hormones (insulin and amylin)

doi: 10.1016/j.diabres.2012.09.008 66 MadsenLWKnaufJAGotfredsenCPillingASjgrenIAndersenSet al

diarrhea, constipation