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Study participants were randomly assigned in a 2:1:1:1:1:2:2 ratio to receive subcutaneous retatrutide 1 mg, 4 mg (starting dose 2 mg), 4 mg (starting dose 4 mg), 8 mg (starting dose 2 mg), 8 mg (starting dose 4 mg), 12 mg (starting dose 2 mg) or placebo once weekly for 48 weeks