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What survives that test is narrower and more testable than the broad claim it replaces: that brain-penetrant agonism, delivered early, in patients chosen by their biology rather than their diagnosis, and judged against biomarkers rather than questionnaires, might still work
But one of the biggest questions patients ask early in their journey is simple: How long do you take GLP-1 for weight loss
Add to that an environment filled with ultraprocessed foods, oversized portions, high stress and limited time for movement, and its no surprise that so many peoples weight ends up yo-yoing despite their best efforts
We start each client at a low dose and carefully monitor weekly to see if an increase is needed