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In the LEADER trial evaluating liraglutide, patients experienced a mean heart rate increase of approximately 3 beats per minute compared to placebo over the study duration
Oliveira, Juan Pablo Arab, Marco Arrese Nature Reviews Gastroenterology & Hepatology .2026;[Epub] CrossRef Alcohol involvement may modify the association between previous hepatitis B virus infection and hepatocellular carcinoma risk in steatotic liver disease Naohiro Yasuura, Goki Suda, Masatsugu Ohara, Daisuke Yokoyama, Takatsugu Tanaka, Akimitsu Meno, Takuya Sho, Risako Kohya, Ruixin Deng, Qingjie Fu, Zijian Yang, Osamu Maehara, Shunsuke Ohnishi, Takashi Kitagataya, Naoki Kawagishi, Masato Nakai, Tatsuhiko K Journal of Gastroenterology .2026;[Epub] CrossRef The changing epidemiology of primary liver cancer in the 21st century Shahid A
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In particular, combining 2-OHNA with other NAD + biosynthesis inhibitors like FK866 effectively kills NAPRT-proficient cancer cells resistant to single-agent treatments 217
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