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In contrast, drugs with a narrow therapeutic window can be particularly vulnerable
Pharmacodynamic markers show that an intervention engaged a pathway
12,13 Modifications to prolong the half-life of GLP-1 RAs include sequence substitutions conferring resistance to DPP-4, along with acylation (liraglutide and semaglutide), covalent bonding to modified Ig fragment crystallisable domain (dulaglutide), or covalent bonding to albumin
Expect a transient GI adjustment period
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