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[13] The doctrine is rooted in several assumptions: (1) prescription pharmaceutical companies have less capacity to communicate efficiently with patients, (2) the average patient generally lacks the ability to understand the pharmaceutical companys warnings and determine if the potential benefits of a particular drug outweigh the potential risks in the patients situation, and (3) physicians are in a better position to warn patients than pharmaceutical companies
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17,18 In ESCC, mutations in TP53, NOTCH1, NFE2L2 , and KMT2D , as well as widespread epigenomic and transcriptomic reprogramming, are prominent features
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