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Evolution of mitochondria as signaling organelles
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Questo fenomeno tanto pi marcato quanto maggiori sono: lentit della perdita ponderale, let del paziente (con lavanzare degli anni la pelle perde progressivamente collagene ed elastina), la durata dellobesit precedente al trattamento, la predisposizione genetica e i fattori ambientali come il fumo e lesposizione solare cronica