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For licensed GLP-1 receptor agonist medicines used for weight management (Wegovy and Saxenda), the side effect profile is well characterised in their UK Summaries of Product Characteristics (SmPCs), available via the electronic Medicines Compendium (emc)

A lot of it comes down to access to healthy food

Gianello (PubMed) Research Focus : Mechanistic Preclinical Research Title : Development of a Human Growth Hormone Peptide Analogue AOD9604 into an Anti-Obesity Drug (Book chapter, Peptides: The Wave of the Future, APSY vol 7, 2001) Authors : Woei-Jia Jiang, Robert Gianello, Mark Heffernan, Esra Ogru, Roksan Libinaki, Frank Ng (SpringerLink) Research Focus : Preclinical Lipid Metabolism Studies (Mice) Title : The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and -AR knockout mice (Endocrinology, Dec 2001) Authors : M

Mood Changes : There have been anecdotal reports of mood swings or changes in emotional well-being, likely due to the changes in energy metabolism

Incomplete Dissolution: Sometimes impatience leads one to use a peptide solution that still has undissolved bits