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The people who are at the highest risk of B12 insufficiency or deficiency are older adults, those with atrophic gastritis, gastrointestinal disorders, pernicious anemia, those who have had gastrointestinal surgery, vegans, and vegetarians

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doi:10.1016/j.mito.2022.05.004 19

Constipation can build more slowly and persist as stomach and intestinal movement slows

Importantly, a decrease in ROS generation has been associated with caloric intake and age, as reported by a pioneering study where the level of mitochondrial superoxide and hydrogen peroxide was significantly higher in mice fed ad libitum vs