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While orforglipron has passed its Phase 3 hurdles without these specific signals so far, the history of pharmacology teaches us that rare, serious adverse events often lurk in the postmarketing shadows

GLP-1 exerts regulatory functions on retinal capillaries and maintains the stability of the blood-retinal barrier, preventing foreign substances from negatively affecting vital retinal neurons

Protective effects of Vitamin E on chemotherapy-induced peripheral neuropathy: a meta-analysis of randomized controlled trials

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2017;11:CD012037