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As of early 2026, the FDA proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B bulks list after stating it did not identify a clinical need for outsourcing facilities to compound those drugs from bulk substances
For instance, 503B facilities have to submit batches for testing and stability along with a self-regulated quality department
GLP-1 receptors are expressed in the hypothalamus, pituitary, ovaries, and uterus
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