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Participants also showed improved cortisol circadian rhythmicity, indicating restored hypothalamic-pituitary-adrenal axis regulation
In addition, sterol regulatory element-binding proteins (SREBPs), such as SREBP-1, in diabetic kidneys aggravated DN by increasing lipid synthesis [237]
The graphical abstract was generated with BioRender (publication license: ET24NGTPGG)
In the long-term, these dynamics are likely to partially or fully resolve
This is why tirzepatide weight loss has shown superior results compared to single-pathway medications
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