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When patients lose weight too quickly, the body depletes fat stores rapidly, including the structural fat in the face and glutes

STEP-1 extension showed semaglutide patients regained two-thirds of their lost weight within a year of stopping, and cardiometabolic improvements largely reversed

Importantly, always consult your practitioner before taking any drugs and adhere to all their guidelines

For many patients, gastrointestinal side effects gradually improve as the body adapts to the medication, though the timeline varies by product and individual

Combined GLP-1 and GIP receptor agonism at appropriate doses shows a safety profile similar to high-dose single-agent therapy, with nausea and gastrointestinal adjustment as the primary tolerability issuestypically resolving within 48 weeks