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Our data not only unveils a previously unknown pathway of ERMCS-localised Gs-coupled GPCR signalling into mitochondria, potentially applicable to other GPCRs beyond the GLP-1R, but also opens the door to further roles of the GLP-1R in the regulation of mitochondrial lipid metabolism, a process tightly linked to changes in mitochondrial morphology and known to be governed by MIC19 activity 11

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Almost 70% of patients choose to stop their GLP-1 treatments before 12 months with nausea and vomiting being the most frequent reasons for discontinuation

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