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A recent study has examined the effect of cobalamin supplementation on the outcomes of treatment for feline patients with severe cobalamin deficiency and histories suggesting chronic gastrointestinal disease.5 In this study, serum concentrations of methylmalonic acid normalized following parenteral cobalamin supplementation, indicating that cobalamin deficiency was the cause of the high methylmalonic acid in serum
15 mg weekly produces ~23% 5 mg every 2 weeks retains ~70% of weekly efficacy Switching from 5 mg weekly to 10 mg every 2 weeks retains 95% of efficacy at 50% of cost non-linear and saturating
Risk Stratification & Contraindications Patient safety must guide the initiation of GLP-1 therapy, and therapy should be withheld if contraindications are present: Absolute Contraindications: Personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Cautionary History: Previous pancreatitis or gastroparesis 5
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TB-500 oral bioavailability unclear Local application Topical or injury-site injection in specific models Combination administration Clinical observations use various routes
