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Like SGLT-2 inhibitors, GLP-1 receptor agonists do not increase the risk of hypoglycemia severe enough to require treatment, but their use can cause gastrointestinal symptoms (NNH = 18

22 One patient had severe acute pancreatitis, and there was one pancreatitis-related death

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These unstable molecules can damage cells, leading to aging, inflammation, and various health issues

These changes improve GnRH pulsatility and ovarian responsiveness