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P., Theocharis, A
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doi: 10.1001/archpsyc.60.4.392
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Early-phase clinical trial data, including results from a Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023), demonstrated significant weight reduction in adults with obesity (without type 2 diabetes), with participants receiving the highest dose losing a mean of approximately 24% of their body weight over 48 weeks
Chromatographic analysis also revealed that in BCA, the content of CA, CDCA, DCA, UDCA, TCDCA, and TDCA exceeded 9.88 g/mg, while the bile acids content in NBC was lower (Ye et al., 2016)
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