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However, GLP-1, in addition to various GLP-1R agonists, is a 300-fold stronger inducer of GSIS (4, 9) and does not produce the effects of glucagon to increase hepatic glucose production, which is thought to be a key pathogenic driver of T2DM (3)

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Spiering, B., Kraemer, W., Hatfield, D., Vingren, J., Fragala, M., Ho, J., Thomas, G., Hkkinen, K