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IGF-1 LR3 is studied for its direct activation of IGF-1 receptors in muscle, adipose, and connective tissue
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The ergogenic effect was explained by the dual role of carnitine glycogen sparing at low intensities and reduced muscle lactate accumulation at high intensities
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However, GIP immunoreactivity was identified in the adult rat brain using a specific monoclonal antibody against GIP (136), suggesting that while GIP is not expressed in the brain, peripheral GIP can reach the deep brain
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