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However, it has also been hypothesized that with time WAMs may become overwhelmed and enter into a senescent state, thereby reducing function and contributing to white matter degeneration and cognitive decline (Ahn et al., 2022)

Under oxidative stress, CSF-cNs upregulated the activity of ATG4 by combining H 2 O 2 with the cysteine 81 sites of ATG4 and activated ATG4-promoted LC3 lipidation, which is essential for autophagy initiation, and promoted the formation of autophagosomes (Scherz-Shouval et al., 2007

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Substantial amounts of NAPQI are effectively eliminated by conjugation with glutathione (GSH)

only the branded versions (Wegovy, Ozempic, Zepbound, Mounjaro, Saxenda, Rybelsus, Trulicity, Victoza) are FDA-approved