The information presented in this activity is not meant to serve as a guideline for patient management
Participants randomized to retatrutide initiated treatment with 2 mg once weekly and increased the dose in a stepwise approach every four weeks until reaching the target dose of 4 mg (via steps at 2 mg and 4 mg), 9 mg (via steps at 2 mg, 4 mg, and 6 mg) or 12 mg (via steps at 2 mg, 4 mg, 6 mg, and 9 mg)
Deep Dive: The GLP-1 Impact Background: Starting Tirzepatide (April 2024) In April 2024, I started Tirzepatide (Mounjaro/Zepbound) at 2.5mg, gradually escalating to 10mg over several months
Therefore, even a disrupted and more permeable BBB can represent a serious challenge to brain-targeted drug delivery
It means that a potential risk has been identified that was not previously known, and the magnitude of that risk has not yet been determined