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Crucially, GLP-1 RAs reduce brain responses to food only after short term treatment (i.e

In addition to GLP-1 in tissues, we used ELISA to detect the level of GLP-1 in serum, and its trend was also consistent with that of GLP-1 in pancreas and intestine (Figure 3E)

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Advise patients that tirzepatide can be administered subcutaneously at any time of day, with or without meals