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Changes in Body Weight at Week 68 in Study 5 (Obesity or Overweight with Comorbidity After 20-week Run-in) with WEGOVY 2.4 mg Injection LSMean = least squares mean

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Accordingly, excess DPP-4, derived from adipocytes and/or hepatocytes, may act as a local mediator of inflammation and adipose/hepatic tissue insulin resistance, thereby forming one link between obesity and the pathogenesis of T2DM and metabolic disease (Figure 3)

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