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Eli Lilly published the results of its ATTAIN-1b trial for obesity in September 2025 7 , which compared orforglipron to placebo in more than 3,100 adults without diabetes, with a BMI of 30+ or 27-30 with an obesity-related complication including hypertension, dyslipidaemia, cardiovascular disease or obstructive sleep apnoea and a history of at least one patient-reported unsuccessful dietary effort to lose body weight, who have tried unsuccessfully to lose weight with diet alone

GLP-1 Longevity of Use The timeline of GLP-1 usage is distinctly different based on the drugs use case

It has a direct effect on both efforts to gain muscle and lose fat

Busam KJ, Shah KN, Gerami P et al

Some insurance plans require step therapy (trying one medication before another), and some providers prefer starting with less potent options