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Additional tests may include full blood count (looking for macrocytic anaemia), methylmalonic acid, and homocysteine levels
The SURPASS-3 MRI substudy added another layer, showing tirzepatide actually reduced muscle fat infiltration across all doses, indicating improved muscle quality even as total muscle volume decreased
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In these cases, injections improve laboratory markers and help resolve symptoms tied to deficiency, such as fatigue, anemia, and certain neurological issues
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