Proliferation (log 2 doublings, 5 days) of indicated GPX4-deficient cell lines in vitro either untreated or supplemented with cholesterol (5 g/mL), combined native LDL and HDL (50 g/mL), combined tristearin-reconstituted LDL and HDL (rLDL+rHDL, 50 g/mL), or Fer-1 (1 M)
When this occurs, additional free radicals are produced which, in turn, can result in more extensive damage to cells and tissues
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Autophagic dysfunction is improved by intermittent administration of osteocalcin in obese mice
These results highlight the superior wound healing ability of G/D-CuP, with healed tissue resembling healthy skin, surpassing outcomes from other treatments